![]() ![]() ![]() Higher success rates have been achieved with carbapenem-containing combinations. Combination therapies not including carbapenems were comparable to aminoglycoside and carbapenem monotherapies. Nevertheless, a review of the literature revealed high failure rates in cases of monotherapy with these drugs, whilst monotherapy with either a carbapenem or an aminoglycoside appeared to be more effective. ![]() Based on susceptibility data, colistin and tigecycline are commonly used to treat CPE infections. Given their multidrug resistance, therapeutic options are limited and, as discussed here, should be reevaluated and optimized. ![]() Carbapenemase-producing enterobacteria (CPE) infect mainly hospitalized patients but also have been spreading in long-term care facilities. The spread of Enterobacteriaceae, primarily Klebsiella pneumoniae, producing KPC, VIM, IMP, and NDM carbapenemases, is causing an unprecedented public health crisis. ![]()
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